72) Grading transplant rejection by endomyocardial biopsy.
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A 50-year-old woman with a history of cardiac transplantation had acute cellular rejection of the transplanted heart. Transthoracic echocardiography, shown in a video, was performed while she was receiving venoarterial extracorporeal membrane oxygenation and revealed ventricular fibrillation with preserved atrial contractility, consistent with atrioventricular dissociation. https://nej.md/2ZKH4f4 | The New England Journal of Medicine
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FacebookThe New England Journal of Medicine
Dr Deshpande's pioneering research on cell-free DNA testing in heart transplants, supported by NIH, aims to detect organ rejection non-invasively. The multi-site clinical validation using the PROSPERA assay, has shown strong performance metrics in detecting acute rejection in both adult and pediatric cohorts. Noninvasive dd-cfDNA technology such as ProsperaTM may reduce the need for surveillance biopsies and enhance the standard of post-transplant care. | Research Features
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CareDx, 10x Genomics partner to decode transplant rejection at cellular resolution
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