Acute promyelocytic leukemia (APL) represents about 10% of acute myeloid leukemias and is characterized by a specific translocation between chromosomes 15 and 17, resulting in the fusion of the ...
Arsenic trioxide (ATO) mediates PML-RARA (promyelocytic leukemia–retinoic acid receptor-α) oncoprotein degradation via the proteasome pathway and this degradation appears to be critical for achieving ...
Rose Ann Padua, Jerome Larghero, Marie Robin, Carol le Pogam, Marie-Helene Schlageter, Sacha Muszlak, Jan Fric, Robert West, Philippe Rousselot, Thi Hai Phan, Liesbeth Mudde, Helene Teisserenc, ...
Acute promyelocytic leukemia (APL) is driven by an oncogenic chromosomal translocation fusing the promyelocytic leukemia (PML) and retinoic acid receptor alpha (RARA) genes. APL responds to two ...
Acute promyelocytic leukemia (APL) is a rare and aggressive form of leukemia, a cancer that affects blood cells. It is caused by a genetic mutation where two genes, PML and RARA, mistakenly fuse ...
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